We have an exciting new product, The Cancer Mutation Census, as well as expertly curated genes and drug resistance data in our July release.
We have been working on an exciting new product - The Cancer Mutation Census (CMC). We are often asked which are the mutations that matter the most, the CMC will help to answer this question! The CMC allows for the prioritisation of somatic mutations that introduce biologically relevant changes to protein function, and participate in the development of cancer.
The CMC integrates all coding somatic mutations collected by COSMIC with biological and biochemical information from multiple sources, combining data obtained from manual curation and computational analyses.
Our team have been working tirelessly to bring a huge amount of data to you in this release! Read about some of the content before heading over to the release notes.
In these trying times we are still producing the COSMIC v91 release for you! We're almost ready but in the meantime, we are sharing some more information about what you can expect to see.
The V91 release is coming soon. Find out about the newly curated genes, plus our other developments for the upcoming release .
There has been recent media coverage, including this Guardian article, about breast implant-associated cancer. The COSMIC Curation team have been hard at work looking into the various aspects of this disease and curating papers for the v91 release in March.
COSMIC version 90 is here. This is a special release for COSMIC because we have focused on updating and upgrading the architecture and systems behind COSMIC, substantially updating and standardising our variant content across current sets of genes, transcripts & proteins.
COSMIC v89 (May 2019) has just been released! In this release we have 4 newly expert-curated genes: DDX3X, LATS1, PIK3CB and NCOR2; and a significant update to bile duct cancer (cholangiocarcinoma).
The COSMIC v88 release is now live! We have 4 newly expert-curated genes: PTPRT, MAP3K1, LEF1 and LATS2; and a significant update to TSC1 and TSC2.
As part of release v88 we have focused on updating the expert-curated mutation data for TSC1 and TSC2 genes. This includes approximately 60 additional publications that include mutation screening data for these genes.
The next COSMIC release is on its way. Traditionally we always have a February release, however, as this one will be such a major release we are delaying it so that we can complete extra testing and make sure we don’t compromise with the quality of data.
The November COSMIC release (v87) is now live! We have 4 newly expert-curated genes, a new fusion pair and a significant update to a further gene. We have continued the disease focussed curation trialled in the last release and this time we have updated the expert-curated mutation data for mesothelioma, a rare and aggressive cancer.
The August COSMIC release (v86) has just gone live! We have 3 newly curated genes: CHD4, IRS4 and CTCF; and the newly curated fusion pair MN1-ETV6. As part of this release we have also completed a body of curation focused on Glioblastoma.
The May COSMIC release (v85) is now live. There are 3 new fully curated genes, substantial curation updates for TERT, 1 new fusion pair, and 162 whole genome screened samples from 8 new systematic screen papers. We have also added 25 new genes to the Cancer Gene Census Hallmarks of Cancer and added a new track to the main Genome Browser which displays mutation recurrence.
The February COSMIC release (v84) has arrived! We have been focusing on curation, with 8 new genes, 2 gene substantial updates and a new fusion pair. There have been over 300 new genomes incorporated from 11 systematic screen papers, as have the updates from the ICGC release 26.
The November release (v83) is now live! New in this release we have 3 fully curated genes: TGFBR2, ERBB4 and BCL9L; a substantial update to VHL; and the new fusion pair ETV6-ABL1. Full details here.
What's new in v82? The August updates include the completion and launch of the restyled website. The full curation of four new genes: BTK, DROSHA, EPAS1 and KEAP1, a substantial update to SMAD4 and a new fusion pair NUP214-ABL1. Full details here.
COSMIC v81 (May 2017) is now live and we have significant new changes to tell you about. For v81 we have a new look website that will run in beta alongside the existing website. We have an exciting new feature - the Hallmarks of Cancer which has been integrated into the Cancer Gene Census pages. Find out more about the release here.