COSMIC Release Update
28 Feb 2019
The next COSMIC release is on its way. Traditionally we always have a February release, however, as this one will be the start of a series of major releases we are delaying it so that we can complete extra testing and make sure we don’t compromise with the quality of data. We'll keep you updated on progress but in the meantime you may be interested to learn more about what's in the near future.
Future releases will include:
- Full reannotation of the entire database using Ensembl's Variant Effect Predictor (VEP) based on Ensembl release 93, in order to have the most up to date genes, transcripts and proteins on both GRCh37 and GRCh38 assemblies.
- Updating the cross-referencelinks between COSMIC genes and other widely-used databases such as HGNC, RefSeq, Uniprot and CCDS.
- Standardising the representation of COSMIC variants, following HGVS recommendations, where possible.
- Remapping of gene fusions on the new updated transcripts on both GRCh37 and GRCh38 assemblies, with the updated syntaxes on the most recent HGVS nomenclature.
- Reducing redundancy, we are collapsing duplicate variants into one representative variant.
What does this mean for you? Cleaner, more consistent data that is up to date with the latest standards, mapped on all versioned transcripts in both GRCh37 and GRCh38 assemblies.